A Homeoprotein Regulates Mitochondrial Function in Cancer

In the study by Papachristodoulou, Abate-Shen and colleagues, published recently in Cancer Discovery  has uncovered a novel nonnuclear function for the prostate specific homeoprotein, NKX3.1, which is a key mechanism for suppression of prostate cancer. Their findings suggest that analyses of the expression levels and subcellular localization of NKX3.1 in patients at risk of cancer progression may improve risk assessment in a precision prevention paradigm, particularly for men undergoing active surveillance. 

NKX3.1 Localization to Mitochondria Suppresses Prostate Cancer Initiation