Current Ph.D. Candidates
Ross plans to rotate in labs studying novel cancer mechanisms and therapeutics through genetic, epigenetic, and immunology lenses.
Emily is working on a translational rodent model of SSRI resistance to understand mechanistic differences between antidepressant pharmacotherapies and determine their unique neurophysiological and behavioral impacts on reward processing.
Tarik studies IgG recycling via the neonatal FcRn receptor in Atherosclerosis and NASH. His key interests are in cardiometabolic diseases, lipid disorders, and liver metabolism.
Jennifer is interested in studying the involvement of the immune system in neurodegenerative disorders and identifying potential therapeutic targets.
Highlights: Moderating a session on Target Therapies at the 2021 Alzheimer's Association APOE and Immunity virtual conference; Presenting a poster entitled "Inhibition of CD33-sialic binding in Late-Onset Alzheimer's Disease"
Alec studies the structure-function relationships of a family of calcium-activated chloride channels called Bestrophins, which are expressed in the eyes and can cause a genetically inherited form of macular degeneration.
Highlights: First-authorship publication in Methods in Enzymology, "Evaluating BEST1 mutations in pluripotent stem cell-derived retinal pigment epithelial cells" and publication in eLife "Distinct expression requirements and rescue strategies for BEST1 loss- and gain-of-function mutations"
Daniel's research approach centers on investigating synthetic lethal approaches to treat pancreatic cancer by targeting cysteine metabolism and inducing ferroptosis, an iron-dependent form of regulated cell death.
Highlights: Publication in Cell during his rotation in the Mancia Lab, "Structural Basis of WLS/Evi-Mediated Wnt Transport and Secretion"; NSF Honorable Mention
Andreacarola's work focuses on immunometabolism as a bridge in the host-pathogen interaction in pulmonary infections.
Highlights: Awarded a National Science Foundation GRFP Fellowship in April of 2021
Xiangyi (Sherry) Ke
Sherry's research interest is in the developmental signaling of lung formation and pulmonary diseases.
Highlights: Currently using single-cell RNA sequencing and combinatorial computational approach to elucidate how specific gene regulatory networks control the formation of the lung primordium, airway branching, and differentiation, and ultimately of lung regeneration and injury repair.
Urszula's current thesis project involves researching a two drug combination as a potential treatment approach for pancreatic cancer. In her research, Urszula uses a variety of genetically engineered mouse models, xenograft models and 2D cultures.
Nicole's research focuses on the development and regulation of adipocytes and the role that they play in conditions such as obesity, diabetes, NASH, and aging.
Highlights: Publication in eLife, "Adipsin promotes bone marrow adiposity by priming mesenchymal stem cells"
Ariana studies the molecular physiology of cardiac regulation. She focuses on the Rad protein, trying to further understand the mechanism of its inhibitory action on Cav1.2.
Cory's research is focused on interactions between the mu opioid and NMDA receptors, and how these interactions may influence behavior in the contexts of stress and antidepressant treatment.
Highlights: Publications in ACS Central Science, "7-Hydroxymitragynine Is an Active Metabolite of Mitragynine and a Key Mediator of Its Analgesic Effects" and Neuropsychopharmacology, "Mu Opioid Receptors on Hippocampal GABAergic Interneurons are Critical for the Antidepressant Effects of Tianeptine" (In press, Accepted).
Caroline is interested in understanding how dopamine receptor signaling gives rise to reward processes and motivated behaviors.
Highlights: Recipient of the Ruth L. Kirschstein Predoctoral Individual National Research Service Award (F31)
Phuc (Leo) Vo
Leo's research interests include developing and using new CRISPR-Cas and gene editing technologies, to engineer genomes of bacterial and mammalian cells.
Highlights: First-authorship publications in Nature Biotechnology, "CRISPR RNA-guided integrases for high-efficiency, multiplexed bacterial genome engineering" and Mobile DNA, "Unbiased profiling of CRISPR RNA-guided transposition products by long-read sequencing"
Ramsey's work pertains to metabolite biosensor development and drug repurposing studies for cardiac arrhythmias in Dr. Masayuki Yazawa's laboratory.
Highlights: First-authorship publications in ScienceDirect, "Timothy syndrome iPSC modeling" and The Journal of Physiology, "The envelope protein of SARS-CoV-2 increases intra-Golgi pH and forms a cation channel that is regulated by pH" and publication in Nature Communications, "Photoactivatable Cre recombinase 3.0 for in vivo mouse applications"
Alan is researching a potential new type of bispecific protein, utilizing a heterodimer-forming scaffold, to facilitate clearance of acute myeloid leukemia by cytotoxic T-cells.
Dallin is currently studying the role of T cells in Alzheimer's disease, and how genetic variation in T cells may alter the progression of neurodegeneration.
Highlights: Recently accepted into TL1 doctoral student training program at Columbia.
Anna is studying non-apoptotic endothelial caspase-9 signaling after retinal vein occlusion and how vascular injury leads to neuronal death. Her goal is to identify different substrates in the mechanism that can be targeted for therapeutic intervention.
Highlights: First author publication in Jove, "Optimization of the Retinal Vein Occlusion Mouse Model to Limit Variability"
Jacob is investigating and testing small molecule therapeutics for neurodegeneration and cancer.
Daniel is working in the lab of Alexander Harris to study the effects of stress on neural circuits underlying reward processing using in vivo electrophysiology and optogenetics.
Highlights: First-authorship publication in Nature Communications, "Ventral tegmental area GABA neurons mediate stress-induced blunted reward-seeking in mice"
For his thesis, Aaron is using single-particle cryogenic electron microscopy (CryoEM) to dissect the molecular mechanisms underlying the function of mammalian bestrophins, a family of calcium-activated anion channels important in eye physiology.
Highlights: First-authorship publication in Nature Structural & Molecular Biology, "Structural and functional characterization of the bestrophin-2 anion channel"
Tamara's thesis work involves characterizing a sensitive adolescent period of development, during which systemic pharmacological administration of antidepressants or stimulants can lead to long-lasting impacts on cocaine reward processing in adulthood.
Highlights: Current Senior Quality Control Fellow for the Columbia Technology Ventures (CTV) Fellows Program tasked with reviewing and managing all early-stage technology assessments