Upcoming Seminar: Dr. Hailing Shi
Hailing Shi, PhD
Helen Hay Whitney Foundation Postdoctoral Fellow
The Broad Institute and the Department of Chemistry at MIT
Hailing received her BS in Chemistry at Peking University, and her Ph.D. in Chemistry at The University of Chicago. Her Ph.D. work focused on context-dependent gene regulatory functions of chemical modifications of RNAs (Nature, 2018). Mapping RNAs in their spatial context with subcellular and molecular resolution in tissues holds great promise in understanding the spatiotemporal regulation of RNA in complex biological functions. Hailing’s post-doctoral research established a comprehensive single-cell resolved spatial cell atlas with molecularly defined cell types, molecularly defined tissue regions, and quantitative recombinant adeno-associated virus (rAAV) accessibility (bioRxiv, 2022). In addition, she developed RNA-based vectors to enable modularized conjugation of enzymatically in vitro transcribed RNA with chemically synthesized oligonucleotides (ACS Chem Bio, 2022). In her independent laboratory, Hailing plans to develop and apply chemical, molecular, and spatial profiling tools to understand the molecular basis of human health and diseases for new therapeutic strategies, including (1) developing spatial mapping methods for RNA modifications in tissues and disease samples; (2) developing spatial functional genomics tools to study cancer progression and therapy responses with multiplexed perturbation and niche profiling; and (3) enabling gene delivery vectors screening in vivo to target specific or previously inaccessible cell types.
Monday December 19, 2022
11:00am – 12:00pm
"Mapping and understanding gene expression in the nervous system with chemical and spatial lenses"