Upcoming Seminar: Dr. Jie Zhou
Jie Zhou, PhD
Post-doctoral Fellow, Laboratory of James Wells
University of California, San Francisco
Jie received her Ph.D. at Brandeis University, and is currently a postdoctoral fellow with Dr. James Wells at UCSF. She has interdisciplinary training in chemical biology, cancer biology, and immunotherapy, and enjoys using the power of synthetic chemistry and protein engineering to study challenging biological problems. Jie’s research is focused on developing enabling technologies for studying and targeting cancer-associated proteins and signaling processes. She has developed enabling technologies to profile how extracellular proteases remodel the tumor microenvironment and to identify upregulated proteolytic events as potential biomarkers and therapeutic targets. She has also studied the consequences of targeting proteolytic neoepitopes with specific recombinant antibodies for cancer therapy. In her independent laboratory, Jie plans to continue to develop novel biotechnologies for studying challenging biological questions and translating her findings into novel therapeutics. Her objectives will be to understand how extracellular enzymes or post-translational modifications (PTMs) contribute to cell signaling and how these enzymes or enzymatic reactions can be exploited for targeted therapy. Her future research should provide foundational insights into the PTM landscape in cancer signaling and drug discovery.
Monday January 23, 2023
11:00am – 12:00pm
"Identifying and targeting proteolytic neoepitopes in cancer"