Susan F. Steinberg, MD

Profile Headshot

Overview

Academic Appointments

  • Professor of Molecular Pharmacology and Therapeutics

Credentials & Experience

Education & Training

  • BS, 1972 Biology, Massachusetts Institute of Technology
  • MD, 1976 Medicine, Harvard Medical School
  • Internship: 1977 Columbia Presbyterian Medical Center, NY
  • Residency: 1979 Columbia Presbyterian Medical Center, NY
  • Fellowship: 1982 Columbia Presbyterian Medical Center, NY

Honors & Awards

Thomas Smith Memorial Lecture, American Heart Associattion, 2019

Research

The studies in my laboratory aim to identify the mechanisms that underlie the physiologically important changes in cardiomyocyte adrenergic receptor responsiveness that accompany normal cardiac development, that influence the evolution of heart failure, or that contribute to cardiac injury in the setting of ischemia-reperfusion injury and oxidative stress. Our studies take advantage of a wide range of reductionist molecular and cell biological approaches in both cell culture and in vitro models to study the expression and subcellular localization of adrenergic receptor subtypes, to identify the adrenergic receptor binding partners and effectors that dictate signaling specificity in cardiomyocytes, and to understand the molecular basis for catecholamine-dependent cardiomyocyte remodeling. One area of particular interest has been the stimulus- (in some cases redox-) dependent post-translational modifications on signaling kinases such as protein kinase C and protein kinase D that alter their enzymology. We also have identified post-translational processing (involving an O-glycan-regulated proteolytic cleavage) of the beta1-adrenergic receptor N-terminus as a mechanism that calibrates signaling output to downstream effector responses. In both cases, these studies identify novel molecular determinants that can serve as druggable targets.