Publications
Selected Recent Publications
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Papachristodoulou, A., Heidegger, I., Virk, R. K., Di Bernardo, M., Kim, J. Y., Laplaca, C., Picech, F., Schäfer, G., De Castro, G. L., Hibshoosh, H., Loda, M., Klocker, H., Rubin, M. A., Zheng, T., Benson, M. C., McKiernan, J. M., Dutta, A., and Abate-Shen, C. (2023). Metformin overcomes the consequences of NKX3.1 loss to suppress prostate cancer progression.(link is external and opens in a new window) European Urology Aug. 31: S0302-2838(23)03016-6/. doi: 10.1016/j.eururo.2023.07.016. PMID: 37659962.
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Vasciaveo, A., Arriaga, J.M., Nunes de Almeida, F., Zou, M., Douglass, E.F., Picech, F., Shibata, M., Rodriguez-Calero, A., de Brot, S., Mitrofanova, A., Chua, C.W., Karan, C., Realubit, R., Pampou, S., Kim, J.Y., Afari, S.N., Mukhammadov, T., Zanella, L., Corey, E., Alvarez, M.J., Rubin, M.A., Shen, M.M., Califano, A., Abate-Shen, C. (2023). OncoLoop: A network-based precision cancer medicine framework.(link is external and opens in a new window) Cancer Discov, 13 (2): 386–409. DOI: 10.1158/2159-8290.CD-22-0342.
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Park, S., Rong, L., Owczarek, T.B., Di Bernardo, M., Shoulson, R.L., Wai Chua, C., Kim, J.Y. Lankarani, A., Chakrapani, P., Syed, T., McKiernan, J.M., Solit, D.B., Shen, M.M., Al-Ahmadie, H., and Abate-Shen, C. (2021). Novel mouse models of bladder cancer identify a prognostic signature associated with risk of disease progression(link is external and opens in a new window). Cancer Research. DOI: 10.1158/0008-5472.CAN-21-1254.
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Papachristodoulou, A., Rodriguez-Calero, A., Panja, S., Margolskee, E., Virk, R. K., Milner, T. A., Pina Martina, L., Kim, J. Y., Di Bernardo, M., Williams, A. B., Maliza, E. A., Caputo, J. M., Haas, C., Wang, V., De Castro, G. J., Wenske, S., Hibshoosh, H., McKiernan, J. M., Shen, M. M., Rubin, M. A., Mitrofanova, A., Dutta, A., and Abate-Shen, C. (2021). NKX3.1 localization to mitochondria suppresses prostate cancer initiation(link is external and opens in a new window). Cancer Discov. 2021 Sep;11(9):2316-2333. PMID: 33893149.
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Arriaga, J. M., Panja, S., Alshalalfa, M., Zhao, J., Zou, M., Giacobbe, A., Madubata, C. J., Kim, J. Y., Rodriguez, A., Coleman, I., Virk, R., Hibshoosh, H., Ertunc, O., Oznek, B., Fountain, J., Karnes, R. J., Luo, J., Antonarakis, E. S., Nelson, P., Feng, F. Y., Rubin, M. A., De Marzo, A. M., Rabadan, R., Sims, P. A., Mitrofanova, A., and Abate-Shen, C.(2020). A MYC and RAS co-activation signature in localized prostate cancer drives bone metastasis and castration resistance(link is external and opens in a new window). Nature Cancer. PMCID: PMC8171279.
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Aytes, A., Giacobbe, A., Mitrofanova, A., Ruggero, K., Cyrta, J., Arriaga, J., Palomero, L., Farran-Matas, S., Rubin, M.A., Shen, M.M., Califano, C., and Abate-Shen, C. (2018). NSD2 is a conserved driver of metastatic prostate cancer progression(link is external and opens in a new window). Nature Communications, 9:5201-5215. PMCID: PMC6281610.
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Zou, M., Toivanen, R., Mitrofanova, A. Floch, N., Hayati, S., Sun, S., Le Magnen, C., Chester, D., Mostaghel, E.A., Califano A, Rubin, M.A., Shen, M.M.*, and Abate-Shen, C.* (2017) Transdifferentiation as a mechanism of treatment resistance in a mouse model of castration-resistant prostate cancer(link is external and opens in a new window). Cancer Discovery, 7: 736-749. (*co-corresponding) PMCID: PMC5501744.
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Le Magnen, C., Virk, R.K, Dutta, A., Kim, J.Y., Panja, S., Lopez-Bujanda, Z.A., Califano, A., Drake, C.G., Mitrofanova, A., and Abate-Shen, C. (2018.) Cooperation of loss of NKX3.1 and inflammation in prostate cancer initiation(link is external and opens in a new window). Disease Models and Mechanisms, Epub 2018/09/30. PMID: 30266798.
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Dutta, A., Panja,S., Virk, R.K., Kim, J.Y., Zott, R., Cremers, S., Golombos, D. M., Liu, D., Mosquera, J.M., Mostaghel, E.A., Barbieri, C.E., Mitrofanova, A.M., and Abate-Shen, C. (2017) Co-clinical analysis of a genetically-engineered mouse model and human prostate cancer reveals significance of NKX3.1 expression for response to 5α-reductase inhibition(link is external and opens in a new window). European Urology, 72: 499-506. PMCID: PMC5600823.
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Dutta, A., Le Magnen, C., Mitrofanova, A., Ouyang, X., Califano, A., and Abate-Shen, C. (2016) Identification of an NKX3.1-G9a-UTY transcriptional regulatory network that controls prostate differentiation(link is external and opens in a new window). Science 352: 1576-1580. PMCID: PMC5507586
Selected Reviews and Commentaries
- Papachristodoulou, A. and Abate-Shen, C. (2022). Precision intervention for prostate cancer: Re-evaluating who is at risk.(link is external and opens in a new window) Cancer Lett. 538: 215709. PMID: 35490919.
- Giacobbe, A. and Abate-Shen, C. (2021). Modeling metastasis in mice: a closer look(link is external and opens in a new window). Trends in Cancer. DOI: https://doi.org/10.1016/j.trecan.2021.06.010(link is external and opens in a new window).
- Arriaga, J.M. and Abate-Shen, C. (2019). Genetically-engineered mouse models of prostate cancer in the post-genomic era(link is external and opens in a new window). Cold Spring Harb Perspect Med, in press. Epub 2018/04/18. PMID: 29661807.
- Le Magnen, C. Shen, MM, and Abate-Shen, C. (2018). Lineage plasticity in cancer progression and treatment(link is external and opens in a new window). Annual Review of Cancer Biology. 2: 271-289. PMCID: PMC5942183.
- Le Magnen, C., Dutta, A., and Abate-Shen, C. (2016). Optimizing mouse models for precision cancer prevention(link is external and opens in a new window). Nat. Rev. Cancer 16: 187-196. PMCID: PMC5517771
- Kobayashi, T., Owczarek, T.B., McKiernan, J.M., and Abate-Shen, C. (2015). Modeling bladder cancer in mice: opportunities and challenges(link is external and opens in a new window). Nat. Rev. Cancer 15: 42-54. PMCID: PMC4386904.
- Shen, M.M., and Abate-Shen, C. (2010). Molecular genetics of prostate cancer: new prospects for old challenges.(link is external and opens in a new window) Genes Dev. 24:1967-2000. PMCID: PMC2939361.
- Abate-Shen, C. (2002). Deregulated homeobox gene expression in cancer: cause or consequence?(link is external and opens in a new window) Nat Rev Cancer 2(10): 777-785. PMID: 12360280
- Abate-Shen, C., and Shen, M. (2000). Molecular genetics of prostate cancer(link is external and opens in a new window). Genes Dev. 14:2410-2434. PMID: 11018010.